The effect of prophylactic chemotherapy on treatment outcome of postmolar gestational trophoblastic neoplasia.

ABSTRACT:

Objective

To evaluate whether prophylactic chemotherapy (P-chem) increased the drug resistance rate of postmolar GTN and whether the first-line chemotherapy should be different from P-chem.

Methods

Postmolar GTN received P-Chem was defined as P-Chem group. Postmolar GTN without P-chem was randomly selected as control group according to the ratio of 1:3 (P-chem:control) and matched by age for low risk and high risk GTN separately.

Results

Totally 455 low-risk and 32 high-risk postmolar GTN patients were included. WHO risk score, chemotherapy cycles to achieve hCG normalization and resistant rate were similar between P-chem (27 cases) and control (81 cases) group. Among low-risk GTN patients, interval from hydatidiform mole to GTN was significantly longer in P-chem grou

SUBMITTER: Liu Y 

PROVIDER: S-EPMC9806869 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature