Systemic Inflammation is Associated with Cardiometabolic Risk Factors and Clinical Outcomes.

ABSTRACT:

Purpose

Assessing an individual's systemic inflammatory state is vital to understand inflammation's role in cardiometabolic diseases and identify those at the greatest risk of disease. We generated global inflammation scores and investigated their associations with cardiometabolic risk factors and adverse outcomes.

Patients and methods

Aggregate Inflammation Scores (AIS) and Principal Component Analysis (PCA) scores were generated for 7287 Framingham Heart Study participants using up to 26 inflammation-related proteins, with higher scores reflecting a pro-inflammatory milieu. Multivariable regression and proportional hazards analyses were conducted to investigate the associations of inflammation with cardiometabolic risk factors and outcomes. The primary outcomes for cross-s

SUBMITTER: Tejada B 

PROVIDER: S-EPMC9807131 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature