Cold shock protein RBM3 is upregulated in the autophagy-deficient brain.

ABSTRACT: Neural autophagy plays an important role in regulating protein quality control, brain homeostasis, and body temperature. However, the mechanism that links a defect in autophagy to body temperature has not been elucidated. Here, we report that RNA binding motif protein 3 (RBM3) is a potential candidate that regulates body temperature. We found that the body temperatures of Nestin-Cre ; Atg7 ^f/f conditional KO (cKO) mice were lower than that of wild-type (WT) mice. Moreover, RBM3 was upregulated in the Nestin-Cre ; Atg7 ^f/f brain. These data suggest that RBM3 is an implicit target that maintains body temperature influenced by neural autophagy.

SUBMITTER: Nakamura J 

PROVIDER: S-EPMC9807172 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature