Systematic analysis of virus nucleic acid sensor DDX58 in malignant tumor.

ABSTRACT:

Introduction

In December 2019, a novel epidemic of coronavirus pneumonia (COVID-19) was reported，and population-based studies had shown that cancer was a risk factor for death from COVID-19 infection. However, the molecular mechanism between COVID-19 and cancer remains indistinct. In this paper, we analyzed the nucleic acid sensor (DDX58) of SARS-CoV-2 virus, which is a significant gene related to virus infection. For purpose of clarifying the characteristics of DDX58 expression in malignant tumors, this study began to systematically analyze the DDX58 expression profile in the entire cancer type spectrum.

Methods

Using TCGA pan-cancer database and related data resources, we analyzed the expression, survival analysis, methylation expression, mutation stat

SUBMITTER: Huang Z 

PROVIDER: S-EPMC9807228 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature