Detergent-Free Decellularization Preserves the Mechanical and Biological Integrity of Murine Tendon.

ABSTRACT: Tissue decellularization has demonstrated widespread applications across numerous organ systems for tissue engineering and regenerative medicine applications. Decellularized tissues are expected to retain structural and/or compositional features of the natural extracellular matrix (ECM), enabling investigation of biochemical factors and cell-ECM interactions that drive tissue homeostasis, healing, and disease. However, the dense collagenous tendon matrix has limited the efficacy of traditional decellularization strategies without the aid of harsh chemical detergents and/or physical agitation that disrupt tissue integrity and denature proteins involved in regulating cell behavior. In this study, we adapted and established the advantages of a detergent-free decellularization method that reli

SUBMITTER: Marvin JC 

PROVIDER: S-EPMC9807253 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature