Complexin Membrane Interactions: Implications for Synapse Evolution and Function.

ABSTRACT: The molecules and mechanisms behind chemical synaptic transmission have been explored for decades. For several of the core proteins involved in synaptic vesicle fusion, we now have a reasonably detailed grasp of their biochemical, structural, and functional properties. Complexin is one of the key synaptic proteins for which a simple mechanistic understanding is still lacking. Living up to its name, this small protein has been associated with a variety of roles differing between synapses and between species, but little consensus has been reached on its fundamental modes of action. Much attention has been paid to its deeply conserved SNARE-binding properties, while membrane-binding features of complexin and their functional significance have yet to be explored to the same degree. In this rev

SUBMITTER: Lottermoser JA 

PROVIDER: S-EPMC9807284 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature