Prognostic Value of Neutrophil-to-Lymphocyte Ratio and Early Standardized Uptake Value Reduction in Patients With Breast Cancer Receiving Neoadjuvant Chemotherapy.

ABSTRACT:

Purpose

We investigated the treatment response and prognosis using the neutrophil-to-lymphocyte ratio (NLR) and standardized uptake value (SUV) of ¹⁸F-fluorodeoxyglucose positron emission tomography (¹⁸F-FDG PET) in neoadjuvant settings.

Methods

Baseline NLR and maximum SUV (SUV_max) were retrospectively analyzed in 273 females with breast cancer who received neoadjuvant chemotherapy followed by surgery. Of these, 101 patients underwent ¹⁸F-FDG PET after 3-4 neoadjuvant chemotherapy cycles, which allowed the measurement of ΔSUV_max, an early reduction in SUV_max. NLR and early SUV_max reduction (ΔSUV_max) were classified as low and high, respectively, relative to the median values.

Results<

SUBMITTER: Bae SJ 

PROVIDER: S-EPMC9807322 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature