Differential Expression in the Tumor Microenvironment of mRNAs Closely Associated with Colorectal Cancer Metastasis.

ABSTRACT:

Background

Metastasis of colorectal cancer (CRC) is a major cause of CRC-related mortality. However, the detailed molecular mechanism of CRC metastasis remains unknown. A recent study showed that the tumor microenvironment, which includes cancer cells and the surrounding stromal cells, plays a major role in tumor invasion and metastasis. Identification of altered messenger RNA (mRNA) expression in the tumor microenvironment is essential to elucidation of the mechanisms responsible for tumor progression. This study investigated the mRNA expression of genes closely associated with metastatic CRC compared with non-metastatic CRC.

Methods

The samples examined were divided into cancer tissue and isolated cancer stromal tissue. The study examined altered mRNA expression in the can

SUBMITTER: Ito K 

PROVIDER: S-EPMC9807483 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature