MicroRNA biomarkers of type 2 diabetes: evidence synthesis from meta-analyses and pathway modelling.

ABSTRACT:

Aims/hypothesis

MicroRNAs are being sought as biomarkers for the early identification of type 2 diabetes. This study aimed to synthesise the evidence from microRNA-type 2 diabetes association studies and microRNA-regulated type 2 diabetes pathway delineation studies that met stringent quality criteria to identify and validate microRNAs of both statistical and biological significance as type 2 diabetes biomarkers.

Methods

Eligible controlled studies on microRNA expression profiling of type 2 diabetes were retrieved from PubMed, ScienceDirect and Web of Science. MicroRNA-regulated type 2 diabetes pathway delineation studies were conducted by integrating and cross-verifying the data from miRTarBase, TransmiR, miRecords, TargetScanHuman, the Kyoto Encyclopedia of Genes and Genom

SUBMITTER: Zhu H 

PROVIDER: S-EPMC9807484 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature