Genetic predisposition to lung adenocarcinoma outcome is a feature already present in patients' noninvolved lung tissue.

ABSTRACT: Emerging evidence suggests that the prognosis of patients with lung adenocarcinoma can be determined from germline variants and transcript levels in nontumoral lung tissue. Gene expression data from noninvolved lung tissue of 483 lung adenocarcinoma patients were tested for correlation with overall survival using multivariable Cox proportional hazard and multivariate machine learning models. For genes whose transcript levels are associated with survival, we used genotype data from 414 patients to identify germline variants acting as cis-expression quantitative trait loci (eQTLs). Associations of eQTL variant genotypes with gene expression and survival were tested. Levels of four transcripts were inversely associated with survival by Cox analysis (CLCF1, hazard ratio [HR] = 1.53; CNTNAP1, H

SUBMITTER: Minnai F 

PROVIDER: S-EPMC9807507 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature