Digging deeper into the immunopeptidome: characterization of post-translationally modified peptides presented by MHC I.

ABSTRACT: Peptides presented by MHC molecules on the cell surface, or the immunopeptidome, play an important role in the adaptive arm of the immune response. Antigen processing for MHC class I molecules is a ubiquitous pathway present in all nucleated cells which generates and presents peptides of both self and non-self-origin. Peptides with post-translational modifications represent one category of peptides presented by MHC class I molecules. However, owing to the complexity of self-peptides presented by cells, the diversity of peptides with post-translational modifications is not well-studied. In this study, we carried out MHC Class I immunopeptidomics analysis of Loucy T-cell leukemia and A375 malignant melanoma cell line to characterize the diversity of post-translational modifications of MHC cl

SUBMITTER: Mangalaparthi KK 

PROVIDER: S-EPMC9807509 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature