Immunoglobulin-like transcript 2 blockade restores antitumor immune responses in glioblastoma.

ABSTRACT: Glioblastoma stands as the most frequent primary brain tumor. Despite the multimodal therapy for glioblastoma patients, the survival rate is very low, highlighting the need for novel therapies that improve patient outcomes. Immune checkpoint blockade strategies are achieving promising results in a myriad of tumors and several studies have reported its efficacy in glioblastoma at a preclinical level. ILT2 is a novel immune checkpoint that exerts an inhibitory effect via the interaction with classical and non-classical HLA class-I molecules. Herein, we report that ILT2 blockade promotes antitumor responses against glioblastoma. In silico and immunohistochemical analyses revealed that the expression of ILT2 and its ligands HLA-A, -B, -C, and -E are highly expressed in patients with glioblasto

SUBMITTER: Lorenzo-Herrero S 

PROVIDER: S-EPMC9807525 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature