Dynamic changes of monocytes subsets predict major adverse cardiovascular events and left ventricular function after STEMI.

ABSTRACT: We explored how dynamic changes in monocyte subset counts (as opposed to static values to specific time points), and their phagocytic and NFκB activity relate to major adverse cardiovascular events (MACE) and left ventricular ejection fraction (LVEF) in patients with ST-elevation myocardial infarction (STEMI). Changes in counts, phagocytic activity and intracellular levels of inhibitory κB kinase β (IKKβ) (a marker of NFκB activity) of monocyte subsets (CD14⁺⁺CD16^-CCR2⁺ [Mon1], CD14⁺⁺CD16⁺CCR2⁺ [Mon2] and CD14⁺CD16⁺⁺CCR2^- [Mon3]) were measured by flow cytometry in patients with STEMI at baseline, and again after one week, two weeks, and one month. LVEF was measured by echocardiography at base

SUBMITTER: Boidin M 

PROVIDER: S-EPMC9807564 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature