Mutation-associated transcripts reconstruct the prognostic features of oral tongue squamous cell carcinoma.

ABSTRACT: Tongue squamous cell carcinoma is highly malignant and has a poor prognosis. In this study, we aimed to combine whole-genome sequencing, whole-genome methylation, and whole-transcriptome analyses to understand the molecular mechanisms of tongue squamous cell carcinoma better. Oral tongue squamous cell carcinoma and adjacent normal tissues from five patients with tongue squamous cell carcinoma were included as five paired samples. After multi-omics sequencing, differentially methylated intervals, methylated loop sites, methylated promoters, and transcripts were screened for variation in all paired samples. Correlations were analyzed to determine biological processes in tongue squamous cell carcinoma. We found five mutated methylation promoters that were significantly associated with mRNA an

SUBMITTER: Liang L 

PROVIDER: S-EPMC9807648 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature