A rare case of unresectable, microsatellite instability-high hepatocellular carcinoma and an examination of the tumor microenvironment.

ABSTRACT: Hepatocellular carcinoma (HCC) is a common cause of cancer-related deaths worldwide, and the mortality rate of patients with unresectable HCC is very high. Microsatellite instability (MSI) is an essential biomarker for response to immune checkpoint inhibitors (ICI) in various tumors. However, the frequency of MSI in HCC is low (1.11%). There is only one case report of MSI-high HCC, and it is not well understood how high MSI affects the tumor microenvironment of HCC. Hence, we describe an interesting patient with unresectable MSI-high HCC, including the evaluation of immune status in the tumor microenvironment. A 68-year-old man presented to our department with HCC in liver segment 1. Contrast-enhanced CT revealed a liver tumor of 6.0 cm in maximum size. The patient underwent extended left

SUBMITTER: Tomiyama T 

PROVIDER: S-EPMC9807723 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature