Cancer risks in rheumatoid arthritis patients who received immunosuppressive therapies: Will immunosuppressants work?

ABSTRACT:

Background

Exploring the cancer risks of rheumatoid arthritis (RA) patients with disease-modifying anti-rheumatic drugs (DMARDs) can help detect, evaluate, and treat malignancies at an early stage for these patients. Thus, a comprehensive analysis was conducted to determine the cancer risk of RA patients using different types of DMARDs and analyze their relationship with tumor mutational burdens (TMBs) reflecting immunogenicity.

Methods

A thorough search of PubMed, EMBASE, Web of Science, and Medline was conducted up to 20 August 2022. Standardized incidence ratios (SIRs) were constructed with a random-effect model to determine risks for different types of malignancies in comparison with the general population. We also analyzed the correlation between SIRs and TMBs using lin

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC9807750 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature