Rapid FEV₁/FVC Decline Is Related With Incidence of Obstructive Lung Disease and Mortality in General Population.

ABSTRACT:

Background

Forced expiratory volume in 1 second (FEV₁)/forced vital capacity (FVC) naturally decreases with age; however, an excessive decline may be related with increased morbidity and mortality. This study aimed to evaluate the FEV₁/FVC decline rate in the Korean general population and to identify whether rapid FEV₁/FVC decline is a risk factor for obstructive lung disease (OLD) and all-cause and respiratory mortality.

Methods

We evaluated individuals aged 40-69 years who underwent baseline and biannual follow-up spirometric assessments for up to 18 years, excluding those with airflow limitations at baseline. Based on the quartiles of the annual FEV₁/FVC decline rate, the most negative FEV₁/FVC change (1^st

SUBMITTER: Choi KY 

PROVIDER: S-EPMC9807769 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature