Vaccine Effect on Household Transmission of Omicron and Delta SARS-CoV-2 Variants.

ABSTRACT:

Background

We evaluated the household secondary attack rate (SAR) of the omicron and delta severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, according to the vaccination status of the index case and household contacts; further, in vaccinated index cases, we evaluated the effect of the antibody levels on household transmission.

Methods

A prospective cross-sectional study of 92 index cases and 197 quarantined household contacts was performed. Tests for SARS-CoV-2 variant type and antibody level were conducted in index cases, and results of polymerase chain reaction tests (during the quarantine period) were collected from contacts. Association of antibody levels in vaccinated index cases and SAR was evaluated by multivariate regression analysis.

Results<

SUBMITTER: Kim YC 

PROVIDER: S-EPMC9807772 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature