Study of epirubicin sustained-release chemoablation in tumor suppression and tumor microenvironment remodeling.

ABSTRACT:

Introduction

Although intratumoral chemoablation can obtain an impressive therapeutic effect, there is still incomplete ablation and tumor recurrence in some patients. This could be due to the short retention time of the drug in the tumor, the limited distribution of intratumoral drugs, and, beyond that, the immunotolerance caused by the tumor microenvironment (TME). There is still an urgent need to find an optimal drug sustained-release carrier and figure out the impact of regional injection to TME.

Methods

In this study, we supposed to use polyethylene glycol (PEG) hydrogel as a drug carrier to improve the retention time of the drug to extend the exposure of tumor cells and investigate the feasibility of combination local Epirubicin injection with anti-PD-L1.

Results

SUBMITTER: Meng L 

PROVIDER: S-EPMC9807901 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature