Low vitamin D concentrations and BMI are causal factors for primary biliary cholangitis: A mendelian randomization study.

ABSTRACT:

Backgrounds

Observational studies have identified associations between smoking, alcohol use, body mass index (BMI), and the levels of vitamin D with primary biliary cholangitis (PBC). However, there was a lack of randomization control studies to estimate the causal relationship. This study was to investigate the causal estimates for the effects of those risk factors on PBC.

Methods

The genetic instrument variants were extracted from genome-wide association studies in European ancestry. Two-sample mendelian randomization (MR) and multivariable mendelian randomization were used to determine genetically causal estimates. Primary analyses consisted of random-effects and fix-mode inverse-variance-weighted methods, followed by secondary sensitivity analyses to verify the results.<

SUBMITTER: Xu H 

PROVIDER: S-EPMC9807903 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature