Distinctive microbiota of delayed healing of oral mucositis after radiotherapy of nasopharyngeal carcinoma.

ABSTRACT:

Background

Oral mucositis is the most common complication after radiotherapy of nasopharyngeal carcinoma (NPC). Previous studies had revealed that oral microbiota took great alteration soon after and during radiotherapy. Here, we aimed to investigate if the alteration of oral microbiota was related to delayed healing of oral mucositis after six month of radiotherapy.

Methods

We recruited 64 NPC patients and collected samples after six month of radiotherapy. 32 patients were included into normal healing group (N), 22 patients were mild delayed healing group (M), while 10 patients were severe delayed healing group (S). 16S rRNA gene sequencing was used to assess and identify oral microbiota alteration.

Results

The diversity of oral microbial communities was not signific

SUBMITTER: Jiang R 

PROVIDER: S-EPMC9807904 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature