Ontology highlight
ABSTRACT:
SUBMITTER: Sun C
PROVIDER: S-EPMC9807961 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
Sun Chuang C Li Wei W Li Yanhong Y Chen Jian J An Huixian H Zeng Guangwei G Wang Tingting T Guo Yazhou Y Wang Changying C
Immune network 20221007 6
Exosomes derived from mesenchymal stem cells (MSCs) could protect against myocardial infarction (MI). TLR4 is reported to play an important role in MI, while microRNA-182-5p (miR-182-5p) negatively regulates TLR4 expression. Therefore, we hypothesize that MSCs-derived exosomes overexpressing miR-182-5p may have beneficial effects on MI. We generated bone marrow mesenchymal stem cells (BM-MSCs) and overexpressed miR-182-5p in these cells for exosome isolation. H<sub>2</sub>O<sub>2</sub>-stimulate ...[more]