From 'Omics to Multi-omics Technologies: the Discovery of Novel Causal Mediators.

ABSTRACT:

Purpose of review

'Omics studies provide a comprehensive characterisation of a biological entity, such as the genome, epigenome, transcriptome, proteome, metabolome, or microbiome. This review covers the unique properties of these types of 'omics and their roles as causal mediators in cardiovascular disease. Moreover, applications and challenges of integrating multiple types of 'omics data to increase predictive power, improve causal inference, and elucidate biological mechanisms are discussed.

Recent findings

Multi-omics approaches are growing in adoption as they provide orthogonal evidence and overcome the limitations of individual types of 'omics data. Studies with multiple types of 'omics data have improved the diagnosis and prediction of disease states and afforded a de

SUBMITTER: Mohammadi-Shemirani P 

PROVIDER: S-EPMC9807989 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature