Prognosis and immune features of pyroptosis-related RNA patterns in low-grade glioma.

ABSTRACT:

Purpose

Low-grade gliomas (LGG), which are malignant primary brain tumors, are more prevalent in young adults. Pyroptosis, an inflammatory form of programmed cell death, has been shown in recent years to be directly associated with tumor growth and tumor microenvironment (TME). However, the correlation between LGG and pyroptosis remained to be explored. In this research, we explored pyroptosis-related gene expression patterns and their prognostic significance based on transcriptome profiles and clinical data in LGG.

Methods

We identified 31 pyroptosis-related genes differentially expressed at the mRNA level between the data of LGG patients from TCGA and the data of normal brain tissues from GTEx. Univariate Cox regression analysis was used to screen 16 differentially express

SUBMITTER: Liu H 

PROVIDER: S-EPMC9808047 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature