Uncovering a 500 million year old history and evidence of pseudogenization for TLR15.

ABSTRACT:

Introduction

Toll like receptors (TLRs) are at the front line of pathogen recognition and host immune response. Many TLR genes have been described to date with some being found across metazoans while others are restricted to specific lineages. A cryptic member of the TLR gene family, TLR15, has a unique phylogenetic distribution. Initially described in extant species of birds and reptiles, an ortholog has been reported for cartilaginous fish.

Methods

Here, we significantly expanded the evolutionary analysis of TLR15 gene evolution, taking advantage of large genomic and transcriptomic resources available from different lineages of vertebrates. Additionally, we objectively search for TLR15 in lobe-finned and ray-finned fish, as well as in cartilaginous fish and jawless vertebr

SUBMITTER: Neves F 

PROVIDER: S-EPMC9808068 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature