N6-methyladenosine (m6A) RNA modification in the pathophysiology of heart failure: a narrative review.

ABSTRACT:

Background and objective

Heart failure is the end-stage of various cardiovascular diseases. Recent progress in molecular biology has facilitated the understanding of the mechanisms of heart failure development at the molecular level. N6-adenosine methylation (m6A) is a post-transcriptional modification of RNA. Recent research work reported that m6A regulates gene expression and subsequently affects the activation of cell signaling pathways related to heart failure. Moreover, m6A regulators like methyltransferase-like 3 (METTL3) were reported to participate in myocardium hypertrophy. However, the current research work related to the role of m6A participating in the occurrence of heart failure is rare in some aspects like immune cell infiltration and diabetic heart diseases. Thus, it

SUBMITTER: Liu S 

PROVIDER: S-EPMC9808110 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature