β3 adrenoceptor agonist mirabegron protects against right ventricular remodeling and drives Drp1 inhibition.

ABSTRACT:

Background

The right ventricular (RV) function determines the prognosis of patients with pulmonary hypertension (PH). Metabolic disorders have been observed in the RV myocardium in PH. Activation of the β3 adrenoceptor improves cardiac function and restores cardiac metabolic efficiency in rodents with heart failure; however, its role in the RV remains uncertain.

Methods

Experimental PH was induced by monocrotaline (MCT) in rats. Mirabegron, a selective β3 adrenoceptor agonist, was given to MCT rats daily from the day after MCT injection at the dose of 10 mg/kg. In vivo echocardiography and RV catheterization were performed to assess RV hemodynamics, structure, and function. RV fibrosis and hypertrophy were assessed by Sirius Red (SR) and wheat germ agglutinin (WGA) st

SUBMITTER: Zhao L 

PROVIDER: S-EPMC9808120 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature