JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy.

ABSTRACT: Identifying and leveraging unique points of metabolic dysregulation in different disease settings is vital for safe and effective incorporation of metabolism-targeted therapies in the clinic. In addition, it has been shown identification of master metabolic transcriptional regulators (MMTR) of individual metabolic pathways, and how they relate to the disease in question, may offer the key to understanding therapeutic response. In prostate cancer, we have previously demonstrated polyamine biosynthesis and the methionine cycle were targetable metabolic vulnerabilities. However, the MMTRs of these pathways, and how they affect treatment, have yet to be explored. We sought to characterize differential sensitivity of prostate cancer to polyamine- and methionine-targeted therapies by identifying

SUBMITTER: Rosario SR 

PROVIDER: S-EPMC9808368 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature