Deciphering the global roles of Cold shock proteins in Listeria monocytogenes nutrient metabolism and stress tolerance.

ABSTRACT: Listeria monocytogenes (Lm) accounts for serious public health and food safety problems owing to its stress resilience and pathogenicity. Based on their regulatory involvement in global gene expression events, cold-shock domain family proteins (Csps) are crucial in expression of various stress fitness and virulence phenotypes in bacteria. Lm possesses three Csps (CspA, CspB, and CspD) whose regulatory roles in the context of the genetic diversity of this bacterium are not yet fully understood. We examined the impacts of Csps deficiency on Lm nutrient metabolism and stress tolerance using a set of csp deletion mutants generated in different genetic backgrounds. Phenotype microarrays (PM) analysis showed that the absence of Csps in ∆cspABD reduces ca

SUBMITTER: Muchaamba F 

PROVIDER: S-EPMC9808409 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature