Clinical and prognostic implications of CD47 and PD-L1 expression in surgically resected small-cell lung cancer.

ABSTRACT:

Background

Pharmacological inhibition of the immune-checkpoint molecule CD47 has shown promising results in preclinical small-cell lung cancer (SCLC) models, whereas anti-programmed death-ligand 1 (PD-L1) inhibitors have been recently implemented in the standard of care of advanced-stage SCLC patients. Nevertheless, the expression pattern, clinical relevance and prognostic implication of both CD47 and PD-L1 are rather controversial in surgically treated SCLC patients.

Materials and methods

In total, 104 Caucasian SCLC patients from two Central European thoracic centers were included in this study. CD47 and PD-L1 expression as well as the expression of the four major SCLC molecular subtype markers (ASCL1, NEUROD1, YAP1 and POU2F3) were measured by immunohistochemistry. Expres

SUBMITTER: Lang C 

PROVIDER: S-EPMC9808447 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature