Antitumor activity of lurbinectedin in combination with oral capecitabine in patients with metastatic breast cancer.

ABSTRACT:

Background

Preclinical studies showed a synergistic effect for 5-fluorouracil and lurbinectedin against solid tumors. This phase I trial evaluated a combination of capecitabine plus lurbinectedin in patients with selected advanced solid tumors. Results in patients with relapsed metastatic breast cancer (MBC) are described.

Patients and methods

Patients received capecitabine daily on day (D)1-D14 combined with lurbinectedin on D1, D8 or D1 every 3 weeks (q3w) intravenously, following a standard 3 + 3 escalation design and expansion at the recommended dose (RD).

Results

Of the 81 enrolled patients, 28 had relapsed MBC: 20 with hormone receptor (HR)-positive tumors and 8 with triple-negative tumors; 3 treated in the D1,D8 schedule and 25 in the D1 schedule. The RD was ca

SUBMITTER: Awada AH 

PROVIDER: S-EPMC9808480 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature