Rare Pulmonary Connective Tissue Type Mast Cells Regulate Lung Endothelial Cell Angiogenesis.

ABSTRACT: Within the human lung, mast cells typically reside adjacent to the conducting airway and assume a mucosal phenotype (MC_T). In rare pathologic conditions, connective tissue phenotype mast cells (MC_TCs) can be found in the lung parenchyma. MC_TCs accumulate in the lungs of infants with severe bronchopulmonary dysplasia, a chronic lung disease associated with preterm birth, which is characterized by pulmonary vascular dysmorphia. The human mast cell line (LUVA) was used to model MC_TCs or MC_Ts. The ability of MC_TCs to affect vascular organization during fetal lung development was tested in mouse lung explant cultures. The effect of MC_TCs on in vitro tube formation and barrier function was studied using primary fetal hu

SUBMITTER: Ren Y 

PROVIDER: S-EPMC9808505 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature