Toward evidence-based severity assessment in mouse models with repeated seizures: (II.) Impact of surgery and intrahippocampal kainate.

ABSTRACT:

Introduction

Chronic epilepsy models require neurosurgical procedures including depth electrode implants. The intrahippocampal kainate model is a frequently used chronic paradigm, which is based on chemoconvulsant administration and status epilepticus induction during the surgical procedure. This experimental approach raises the question to what extent this approach affects post-surgical recovery. In addition to the short- and long-term impact of the surgical intervention, a potential impact of highly frequent electrographic seizure events needs to be considered in the context of severity assessment.

Methods

Various behavioral, biochemical, and telemetric parameters were analyzed in four experimental groups of mice: 1st naive, 2nd with transmitter implants, 3rd with transmit

SUBMITTER: Buchecker V 

PROVIDER: S-EPMC9808668 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature