Passive biaxial mechanical behavior of newborn mouse aorta with and without elastin.

ABSTRACT: Aortic wall material properties are needed for computational models and for comparisons across developmental and disease states. There has been abundant work in comparing aortic material properties across disease states, but limited work across developmental states. We performed passive biaxial mechanical testing on newborn mouse aorta with (Eln^+/+) and without (Eln^-/-) elastin. Elastin provides elasticity to the aortic wall and is necessary for survival beyond birth in the mouse. Mechanically functional elastin is challenging to create in vitro and so Eln^-/- aorta can be a comparison for tissue engineered arteries with limited elastin amounts. We found that a traditional arterial strain energy function provided reasonable fits to newborn mouse aorta and ge

SUBMITTER: Kim J 

PROVIDER: S-EPMC9808670 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature