Dual-stimuli responsive smart nanoprobe for precise diagnosis and synergistic multi-modalities therapy of superficial squamous cell carcinoma.

ABSTRACT:

Background

Although the promising advancements of current therapeutic approaches is available for the squamous cell carcinoma (SCC) patients, the clinical treatment of SCC still faces many difficulties. The surgical irreparable disfigurement and the postoperative wound infection largely hamper the recovery, and the chemo/radiotherapy leads to toxic side effects.

Results

Herein, a novel pH/Hyaluronidase (HAase) dual-stimuli triggered smart nanoprobe Fe^IIITA@HA has been designed through the biomineralization of Fe³⁺ and polyphenol tannic acid (TA) under the control of hyaluronic acid (HA) matrix. With the HA residues on the outer surface, Fe^IIITA@HA nanoprobes can specifically target the SCC cells through the over-expressed CD44, and accumulate

SUBMITTER: Zhang P 

PROVIDER: S-EPMC9808965 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature