A proteomic profile of the healthy human placenta.

ABSTRACT:

Background

The placenta remains one of the least studied organs within the human body. Yet, placental dysfunction has been associated with various pregnancy complications leading to both maternal and fetal death and long-term health consequences. The aim of this study was to characterise the protein networks of healthy term placental sub-anatomical regions using label free quantification mass spectrometry.

Methods

Three healthy placentae were sampled at five sample sites and each biopsy was dissected into maternal-, middle-, and fetal- sub-anatomical regions. Quadrupole-orbitrap mass spectrometer was used in data dependant analysis mode to identify 1859 unique proteins before detailed differential expression between regions.

Results

Protein profiling identified 1081,

SUBMITTER: Manna S 

PROVIDER: S-EPMC9808999 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature