Metataxonomic and metaproteomic profiling of the oral microbiome in oral lichen planus - a pilot study.

ABSTRACT:

Background

A growing body of evidence demonstrates a different bacterial composition in the oral cavity of patients with oral lichen planus (OLP).

Patients and methods

Buccal swab samples were collected from affected and non-affected sites of six patients with reticular OLP and the healthy oral mucosa of six control subjects. 16S rRNA gene MiSeq sequencing and mass spectrometry-based proteomics were utilised to identify the metataxonomic and metaproteomic profiles of the oral microbiome in both groups.

Results

From the metataxonomic analysis, the most abundant species in the three subgroups were Streptococcus oralis and Pseudomonas aeruginosa, accounting for up to 70% of the total population. Principal Coordinates Analysis showed differential clustering of samples fro

SUBMITTER: Bankvall M 

PROVIDER: S-EPMC9809343 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature