Remdesivir improves biomarkers associated with disease severity in COVID-19 patients treated in an outpatient setting.

ABSTRACT:

Background

Remdesivir (RDV) is an intravenous antiviral with activity against SARS-CoV-2 for treatment of hospitalized COVID-19 patients with moderate-to-severe disease. Biomarkers associated with clinical outcomes have been identified for COVID-19, but few evaluated in context of antiviral treatment. Here, we assessed baseline (day 1, prior to first RDV dose) biomarkers and the impact of RDV treatment on longitudinal biomarker readouts.

Methods

Recently, RDV was evaluated in high-risk, non-hospitalized patients with confirmed SARS-CoV-2 infection and was highly effective at preventing disease progression. The randomized, double-blind, placebo-controlled Phase 3 study included 562 participants who received at least 1 dose of study drug, of which 312 consented for longitudina

SUBMITTER: Pan DZ 

PROVIDER: S-EPMC9809529 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature