Remodeling of Architected Mesenchymal Microtissues Generated on Mechanical Metamaterials.

ABSTRACT: Mechanical metamaterials constitute a nascent category of architected structures comprising arranged periodic components with tailored geometrical features. These materials are now being employed as advanced medical implants due to their extraordinary mechanical properties over traditional devices. Nevertheless, to achieve desired tissue integration and regeneration, it is critical to study how the microarchitecture affects interactions between metamaterial scaffolds and living biological tissues. Based on human induced pluripotent stem cell technology and multiphoton lithography, we report the establishment of an in vitro microtissue model to study the integration and remodeling of human mesenchymal tissues on metamaterial scaffolds with different unit geometries. Microtissues show

SUBMITTER: Wang C 

PROVIDER: S-EPMC9809979 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature