Two distinct resident macrophage populations coexist in the ovary.

ABSTRACT:

Introduction

Tissue-resident macrophages (TRMs) are highly heterogeneous and have a complex and important role in tissue support, homeostasis, and function. The heterogeneity, maintenance, and function of TRMs, as one of the major immune cells in the ovary, are not well understood.

Methods

Application of flow cytometry, Parabiosis, Fate mapping, Macrophage depletion, etc.

Results

Here, we described two distinct macrophage subsets, F4/80^hiCD11b^int and F4/80^intCD11b^hi, with different phenotypic characteristics in the ovary of mice. The F4/80^hiCD11b^int population contained a distinct CD206⁺ subgroup and highly expressed CD81, while the F4/80^intCD11b^hi subset showed higher e

SUBMITTER: Li N 

PROVIDER: S-EPMC9810109 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature