Development of specialized magnetic resonance acquisition techniques for human hyperpolarized [¹³ C,¹⁵ N₂ ]urea + [1-¹³ C]pyruvate simultaneous perfusion and metabolic imaging.

ABSTRACT:

Purpose

This study aimed to develop and demonstrate the in vivo feasibility of a 3D stack-of-spiral balanced steady-state free precession(3D-bSSFP) urea sequence, interleaved with a metabolite-specific gradient echo (GRE) sequence for pyruvate and metabolic products, for improving the SNR and spatial resolution of the first hyperpolarized ¹³ C-MRI human study with injection of co-hyperpolarized [1-¹³ C]pyruvate and [¹³ C,¹⁵ N₂ ]urea.

Methods

A metabolite-specific bSSFP urea imaging sequence was designed using a urea-specific excitation pulse, optimized TR, and 3D stack-of-spiral readouts. Simulations and phantom studies were performed to validate the spectral response of the sequence. The image quality of urea data acqui

SUBMITTER: Liu X 

PROVIDER: S-EPMC9810116 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature