Construction and validation of nomograms combined with novel machine learning algorithms to predict early death of patients with metastatic colorectal cancer.

ABSTRACT:

Purpose

The purpose of this study was to investigate the clinical and non-clinical characteristics that may affect the early death rate of patients with metastatic colorectal carcinoma (mCRC) and develop accurate prognostic predictive models for mCRC.

Method

Medical records of 35,639 patients with mCRC diagnosed from 2010 to 2019 were obtained from the SEER database. All the patients were randomly divided into a training cohort and a validation cohort in a ratio of 7:3. X-tile software was utilized to identify the optimal cutoff point for age and tumor size. Univariate and multivariate logistic regression models were used to determine the independent predictors associated with overall early death and cancer-specific early death caused by mCRC. Simultaneously, predictive and

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC9810140 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature