HRG-9 homologues regulate haem trafficking from haem-enriched compartments.

ABSTRACT: Haem is an iron-containing tetrapyrrole that is critical for a variety of cellular and physiological processes^1-3. Haem binding proteins are present in almost all cellular compartments, but the molecular mechanisms that regulate the transport and use of haem within the cell remain poorly understood^2,3. Here we show that haem-responsive gene 9 (HRG-9) (also known as transport and Golgi organization 2 (TANGO2)) is an evolutionarily conserved haem chaperone with a crucial role in trafficking haem out of haem storage or synthesis sites in eukaryotic cells. Loss of Caenorhabditis elegans hrg-9 and its paralogue hrg-10 results in the accumulation of haem in lysosome-related organelles, the haem storage site in worms. Similarly, deletion of the hrg-9 homologue TANGO2 in yeas

SUBMITTER: Sun F 

PROVIDER: S-EPMC9810272 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature