Actin depolymerizing factor-based nanomaterials: A novel strategy to enhance E. mitis-specific immunity.

ABSTRACT: The epidemic of avian coccidiosis seriously threatens the animals' welfare and the economic gains of the poultry industry. Widespread in avian coccidiosis, Eimeria mitis (E. mitis) could obviously impair the production performance of the infected chickens. So far, few effective vaccines targeting E. mitis have been reported, and the nanovaccines composed of nanospheres captured our particular attention. At the present study, we construct two kinds of nanospheres carrying the recombinant E. mitis actin depolymerizing factor (rEmADF), then the characterization was then analyzed. After safety evaluation, the protective efficacy of rEmADF along with its nanospheres were investigated in chickens. The promoted secretions of antibodies and cytokines, as well as the enh

SUBMITTER: Yu Z 

PROVIDER: S-EPMC9810622 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature