Extracellular vesicles and insulin-mediated vascular function in metabolic syndrome.

ABSTRACT: Metabolic Syndrome (MetS) raises cardiovascular disease risk. Extracellular vesicles (EVs) have emerged as important mediators of insulin sensitivity, although few studies on vascular function exist in humans. We determined the effect of insulin on EVs in relation to vascular function. Adults with MetS (n = 51, n = 9 M, 54.8 ± 1.0 years, 36.4 ± 0.7 kg/m² , ATPIII: 3.5 ± 0.1 a.u., VO₂ max: 22.1 ± 0.6 ml/kg/min) were enrolled in this cross-sectional study. Peripheral insulin sensitivity (M-value) was determined during a euglycemic clamp (40 mU/m² /min, 90 mg/dl), and blood was collected for EVs (CD105+, CD45+, CD41+, TX+, and CD31+; spectral flow cytometry), inflammation, insulin, and substrates. Central hemodynamics (applanation tonometry) was determined at

SUBMITTER: Ragland TJ 

PROVIDER: S-EPMC9810789 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature