Serum metabolic signatures of schizophrenia patients complicated with hepatitis B virus infection: A ¹H NMR-based metabolomics study.

ABSTRACT:

Introduction

Schizophrenia (SZ) is a severe chronic mental disorder with increased risk of hepatitis B virus (HBV) infection, which is incurable currently and induces various negative emotions and psychological pressures in patients to exacerbate mental disorders. To facilitate the therapeutic design for SZ patients complicated with HBV infection (SZ + HBV), it is helpful to first elucidate the metabolic perturbations in SZ + HBV patients.

Methods

In this study, metabolic profiles of the serum samples from four groups of participants comprising healthy controls (HC, n = 72), HBV infection (n = 52), SZ patients (n = 37), and SZ + HBV (n = 41) patients were investigated using a high-resolution ¹H NMR-based metabolomics approach.

Result

SUBMITTER: Lin C 

PROVIDER: S-EPMC9810819 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature