Possible Harmful Effects of Smoking Hookah on Sperm DNA Fragmentation Index and Protamine Genes Expression in Normozoospermic Men.

ABSTRACT:

Objectives

In recent years, smoking water pipes or hookah has increased among adolescents in most countries. Although there is evidence in support of the negative effects of this type of smoking on human health, such as the increased risk of lung disease, little is known about the potential effects of hookah smoking on the male reproductive system, especially on the molecular aspects of sperm.

Patients and methods

This cross-sectional study examined sperm DNA fragmentation index, protamine 1 and 2 (PRM1 and PRM2) genes expression, and oxidant status in normozoospermic hookah smokers in comparison with non-smoker controls.

Results

Our results showed significantly higher rates of DNA fragmentation, protamine deficiency, and abnormal chromatin condensation

SUBMITTER: Tofighi Niaki M 

PROVIDER: S-EPMC9810994 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature