Genetic characterization and molecular epidemiology of Coxsackievirus A12 from mainland China during 2010-2019.

ABSTRACT: Coxsackievirus A12 (CVA12) is an enterovirus that has been isolated in many countries in recent years. However, studies on CVA12 are limited, and its effective population size, evolutionary dynamics and recombination patterns have not been clarified now. In this study, we described the phylogenetic characteristics of 16 CVA12 strains isolated from pediatric HFMD patients in mainland China from 2010 to 2019. Comparison of the nucleotide sequences and amino acid sequences with the CVA12 prototype strain revealed that the 16 CVA12 strains are identical in 78.8-79% and 94-94.2%, respectively. A phylodynamic analysis based on the 16 full-length VP1 sequences from this study and 21 sequences obtained from GenBank revealed a mean substitution rate of 6.61 × 10^-3 substitutions/site/year

SUBMITTER: Guo Q 

PROVIDER: S-EPMC9811122 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature