Effects of polygenic risk for major mental disorders and cross-disorder on cortical complexity.

ABSTRACT:

Background

MRI-derived cortical folding measures are an indicator of largely genetically driven early developmental processes. However, the effects of genetic risk for major mental disorders on early brain development are not well understood.

Methods

We extracted cortical complexity values from structural MRI data of 580 healthy participants using the CAT12 toolbox. Polygenic risk scores (PRS) for schizophrenia, bipolar disorder, major depression, and cross-disorder (incorporating cumulative genetic risk for depression, schizophrenia, bipolar disorder, autism spectrum disorder, and attention-deficit hyperactivity disorder) were computed and used in separate general linear models with cortical complexity as the regressand. In brain regions that showed a significant associatio

SUBMITTER: Schmitt S 

PROVIDER: S-EPMC9811276 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature