Associations and limited shared genetic aetiology between bipolar disorder and cardiometabolic traits in the UK Biobank.

ABSTRACT:

Background

People with bipolar disorder (BPD) are more likely to die prematurely, which is partly attributed to comorbid cardiometabolic traits. Previous studies report cardiometabolic abnormalities in BPD, but their shared aetiology remains poorly understood. This study examined the phenotypic associations and shared genetic aetiology between BPD and various cardiometabolic traits.

Methods

In a subset of the UK Biobank sample (N = 61 508) we investigated phenotypic associations between BPD (ncases = 4186) and cardiometabolic traits, represented by biomarkers, anthropometric traits and cardiometabolic diseases. To determine shared genetic aetiology in European ancestry, polygenic risk scores (PRS) and genetic correlations were calculated between BPD and cardiometabolic trait

SUBMITTER: Furtjes AE 

PROVIDER: S-EPMC9811277 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature